Compartmentation in the Induction of the Hexose-6-Phosphate Transport System of Escherichia coli1
J Bacteriol. 1970 Feb;101(2):470–475. doi:
Compartmentation in the Induction of the Hexose-6-Phosphate Transport System of Escherichia coli
Herbert H Winkler
aDepartment of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22903Find articles by
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aDepartment of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 229031 Presented in part at the 69th Annual Meeting of the American Society for Microbiology, 4–9 May 1969, Miami, Fla.
Copyright © 1970 American Society for Microbiology
PMCID: PMC284930 PMID:
Abstract
The induction of the hexose-6-phosphate transport system was investigated. Glucose-6-phosphate (G6P) at concentrations as low as 10−4m was able to induce this system in wild-type cells, as well as in mutants lacking phosphoglucose isomerase or G6P dehydrogenase. Growth in the presence of fructose-6-phosphate (F6P) induced the system only if the cells contained phosphoglucose isomerase. Furthermore, glucose and F6P were found to induce the system only if the extracellular concentration of G6P became appreciable in the medium as a consequence of the leakage of intracellular G6P formed from the glucose or F6P. Intracellular G6P was not an inducer even at high concentrations. The metabolism of glucose inhibited the induction of the hexose-6-phosphate transport system. Hypotheses for this compartmentalization of inducer and membrane-associated induction are presented.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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