Vascular Disease

Written by WebMD Editorial Contributors · WebMD

Vascular disease

is any condition that affects the network of your blood vessels.

This network is known as your vascular or circulatory system. "Vascular" comes from a Latin word for hollow container. If your entire network of blood vessels were stretched end-to-end, they could circle the Earth multiple times.

Some of these vessels move

blood

. As your

heart

beats, it pumps blood with oxygen and nutrients to feed your tissues and carry off waste.

Arteries

move blood away from the heart. Veins return it.

Lymph vessels and

lymph nodes

are part of a separate cleaning system that rids your body of damaged cells. They also help protect you from infections and

cancer

. The vessels pick up fluid from tissues throughout your body. That fluid drains back into veins under your collarbones.

Vascular diseases

range from problems with your arteries, veins, and vessels that carry lymph to disorders that affect how your blood flows. A disease can mean your tissues aren’t getting enough blood, a condition called

ischemia

, as well as other serious, even life-threatening, problems.

Aneurysm

An aneurysm is a bulge in the wall of any blood vessel. It's most often seen in the

aorta

, the main blood vessel leaving your

heart

. You can get an

aortic aneurysm

in your chest, where it's called thoracic, or your belly, where it's called abdominal.

Small aneurysms generally pose no threat. But they put you at risk for other problems:

Plaque deposits may build up where the aneurysm is.

A clot may form there and then break off and get stuck somewhere else, which could be very dangerous.

The aneurysm might get bigger and press on other organs, which causes pain.

Because the artery wall is stretched and thinner at the spot of an aneurysm, it's fragile and could burst under stress, like a balloon. The sudden rupture of an aortic aneurysm can be deadly.

Atherosclerosis

and

peripheral artery disease

Coronary arteries supply blood to your heart muscle. Peripheral arteries carry blood to other tissues and organs. Both can have deposits of fat,

cholesterol

, and other substances on their inside walls called plaque. Over time, plaque can build up, so the vessel becomes narrow and it’s harder for blood to flow. Or a plaque could rupture, blocking blood flow.

Eventually, the artery will be so narrow that your tissues don't get enough blood. You can have different symptoms and problems, based on where it happens. For example:

Blockage in coronary arteries can cause

chest pain

(

angina

) or a

heart attack

.

If it's in the carotid arteries that supply

your brain

, it can lead to a stroke or mini stroke, which is called a transient ischemic attack (TIA).

Blockage in the

kidneys

can lead to trouble with how they work, uncontrolled

high blood pressure

, and

heart failure

.

A blockage in your leg can lead to

leg pain

or

cramps

when you're active -- a condition called claudication -- a

skin

color change, sores or ulcers, and your legs feeling

tired

.

When you don't have any blood flow to a part of your body, the tissues could die. If that happens, you may lose a limb or an organ.

Blood clots

in veins (VTE)

A

blood clot

in a vein inside a muscle -- usually in your lower leg, thigh, or pelvis -- is a

deep vein thrombosis (DVT)

. If the clot breaks loose and travels to your

lungs

, it becomes a

pulmonary embolism

(PE). Your doctor may call these clots in your veins venous thromboembolisms, or VTE.

Causes include:

Conditions that slow blood flow or make blood thicker, such as

congestive heart failure

and certain tumors

Damaged valves in a vein

Damaged veins from an injury or infection

Genetic disorders that make your blood more likely to clot

Hormones, such as

estrogen

from

pregnancy

and

birth control pills

Long

bed rest

or not being able to move much

Surgery, especially some operations on your hips and legs

Damaged vein valves or a

DVT

can cause long-term blood pooling and swelling in your legs, too. That problem is called chronic venous insufficiency. If you don't do anything about it, fluid will leak into the tissues in your

ankles

and

feet

. Over time, it may make your skin break down and wear away.

Blood clotting disorders

Some illnesses make your blood more likely to form clots. You could be born with one, or something may happen to you. These types of disorders can cause:

Higher-than-normal levels of clot-forming substances, including fibrinogen, factor 8, and prothrombin

Not enough blood-thinning (anticoagulant) proteins, including antithrombin, protein C, and protein S

Trouble breaking down fibrin, the protein mesh that holds clots together

Damage to the endothelium, the lining of your blood vessels

Buerger's disease

This rare disease most often happens in the small and medium arteries and veins in your arms and legs. They swell up and may form clots, cutting off blood supply to your fingers, hands, toes, or feet. These body parts will hurt, even when you're resting. If it's severe, you might lose fingers or toes.

Although we don’t know what causes it, there's a strong tie to

tobacco

use -- including

cigars

and chewing tobacco -- and

secondhand smoke

.

Lymphedema

Your lymphatic system doesn't have a pump, the way your blood circulation system does. It relies on valves in the vessels and muscle contractions to keep the lymph moving.

When vessels or nodes are missing or don't work right, fluid can build up and cause swelling, most often in your arms or legs. This is called lymphedema.

Primary lymphedema is rare. It happens when you're born without certain lymph vessels or when you have a problem with the tubes themselves.

When there’s a blockage or pause in your lymphatic system, it’s called secondary lymphedema. It can happen because of:

Cancer and cancer treatments, including

radiation

Deep vein thrombosis (DVT)

Infection

Scar tissue formation

Serious injury

Surgery

Peripheral venous disease and

varicose veins

Unlike arteries, veins have flaps inside called valves. When your muscles contract, the valves open, and blood moves through the tubes. When your muscles relax, the valves close so the blood flows in only one direction.

Damaged valves may not close the way they should when your muscles relax. This allows blood to flow in both directions, and it can pool.

This is what happens with

varicose veins

. They may bulge like purple ropes under your skin. They can also look like small red or purple bursts on your knees,

calves

, or thighs. These spider veins happen because of swollen small blood vessels called capillaries. After a day of activity, your legs might ache, sting, or swell.

More women than men get varicose veins, and they often run in families. Pregnancy, being very

overweight

, or standing for long times can cause them.

Because your blood is moving more slowly, it may stick to the sides of your veins, and clots can form.

Raynaud's phenomenon

(Raynaud's disease or Raynaud's syndrome)

When you're cold or excited, the small arteries of your fingers and your toes may

twitch

or cramp. This can temporarily shut down blood supply to the area, making your skin look white or bluish and

feel cold

or numb.

The working conditions of some jobs bring on Raynaud's. The symptoms could also be related to other diseases, including

lupus

,

rheumatoid arthritis

, and

scleroderma

.

People with Buerger’s disease can also have Raynaud’s phenomenon.

Vascular disease

causes can include:

Atherosclerosis, the buildup of plaque in your arteries

Blockage in your blood vessel by a mass of debris (embolus) or blood clot (thrombus)

Inflammation

, called vasculitis

Trauma or injury

Some things can

increase your risk

of getting a vascular disease, including:

Diabetes

Family history

of vascular disease, heart attack, or

stroke

Gender. (Men are at higher risk than women.)

High blood pressure

High levels of fats like cholesterol and

triglycerides

Lack of

physical activity

Being

overweight

or

obese

Smoking

Stress

You can often

treat vascular disease

with lifestyle changes, such as:

A healthy diet to help lower your

blood sugar

or cholesterol

Exercise

Quitting tobacco

Stress management

You may also need

medication

, including:

Blood pressure drugs

Cholesterol medication

Drugs to prevent blood clots

If your case is serious, you might need a medical procedure like an

angioplasty

, in which your doctor widens or clears a blood vessel.

If you haven’t been diagnosed with

vascular disease

, some of those lifestyle changes can help keep you healthy. Eat a good

diet

,

exercise

regularly, and don’t smoke.